A remarkable archaeological discovery in northern Türkiye is rewriting the history of prehistoric medicine. A human skull, dating back nearly 5,000 years, has been found at İkiztepe Höyüğü (İkiztepe mound), and experts say it bears evidence of one of the earliest known cranial surgeries in Anatolia.
The skull, now displayed at the Samsun Museum, shows signs of intentional surgical intervention, suggesting that early Anatolian communities may have practiced advanced medical procedures long before formal medicine emerged in the ancient world.
Evidence of Survival After Surgery
What makes this discovery especially significant is the clear evidence that the individual survived the operation for some time. The healed edges around the surgical incision indicate that the body had time to recover, which implies knowledge of post-operative care and infection control.
Such findings challenge traditional assumptions about prehistoric healthcare and indicate that early Anatolian societies may have developed medical practices based on experience and observation.
İkiztepe Höyüğü: A Key Prehistoric Site
İkiztepe Höyüğü is one of the most important archaeological sites in the Central Black Sea region, revealing extensive burial practices and prehistoric settlement life. Excavations have uncovered a variety of burial goods, including spearheads and personal objects placed with the dead—suggesting social hierarchies and symbolic funerary rituals.
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Located near the modern city of Samsun, İkiztepe has been known for its deep cultural layers, dating back to the Chalcolithic period and continuing into the Bronze Age. The site has produced important evidence of early settlement patterns, trade, and cultural development in northern Anatolia.

Aşıklı Höyük and Çatalhöyük: Similar Medical Evidence
The İkiztepe discovery is not an isolated case. Archaeologists have found similar surgical evidence at other ancient Anatolian sites, including Aşıklı Höyük and Çatalhöyük, which are among the oldest known settlements in the region.
At Aşıklı Höyük, located in Central Anatolia, researchers have documented early signs of skull modifications and possible therapeutic interventions, suggesting that prehistoric communities may have practiced primitive forms of surgery.
Likewise, Çatalhöyük, one of the world’s most famous Neolithic sites, has yielded skeletal remains with signs of cranial manipulation, indicating that prehistoric Anatolians may have developed early medical knowledge through trial, observation, and cultural practices.
These discoveries together indicate that Anatolia was likely a center for early medical experimentation, and that prehistoric societies may have shared knowledge across regions through migration and trade.
The Importance of the Samsun Museum Collection
The skull is now housed in the Samsun Museum, alongside other notable artifacts that highlight the region’s long and diverse history. Among the museum’s most prominent exhibits are the Amisos Treasures, a collection of gold objects dating from the 7th to 5th centuries BC, showcasing the advanced craftsmanship and artistic sophistication of ancient Anatolian societies.
The museum also displays the Amisos Mosaic, a rare sand-based mosaic depicting the personification of the four seasons. This piece is considered one of the few surviving examples of its kind in Turkey and reflects the region’s rich artistic traditions.

A New Perspective on Prehistoric Anatolia
The discovery at İkiztepe adds a new dimension to our understanding of prehistoric Anatolia. It suggests that early human societies in the region were not only capable of complex social organization and artistry but also possessed advanced medical knowledge.
Experts believe that these findings could reshape the narrative of early medicine, highlighting Anatolia as a critical center for innovation in healthcare long before the rise of classical civilizations.
As visitors explore the Samsun Museum, they are reminded of the deep history that lies beneath the Black Sea region—where prehistoric surgery, elite craftsmanship, and ancient art combine to tell a story that spans thousands of years.
Cover Image Credit: İHA

